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The researchers noted that this signal is strongest in women

Available at: Koohpeyma, F., Gholizadeh, F., Hafezi, H., Hajiaghayi, M., Siri, M., Allahyari, S., Maleki, M

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Targeting energy metabolism for autoimmune disease therapy Energy metabolism is a critical factor in the pathogenesis of autoimmune diseases, particularly in supporting the proliferation and function of activated T and B cells, which have high energy demands

Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output